BIOB10H3 Lecture Notes - Lecture 12: Plectin, Hemidesmosome, Fimbrin
15 Jun 2018
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Lecture 12
Sperm
• Function
o SWIM! bind & dissolve egg coat (by acrosome)
• Cell Specializations:
o Flagella: MTs and MT motor dynein (ATPase)
o Inc # of Mitochondria - ATP
o Small Cell with Condensed streamlined head – supercoiled DNA to make small
nucleus, ↑↑ # histone proteins
o Acrosome – secretory lysosome – secreted via kinesin along MTs
Neuron
• Function
o nerve impulses and formation and secretion of secretory vesicles
• Cell Specializations:
o Nerve impulses: Na+/K+ pump, channels, etc.
o Inc # of mitochondria – ATP
o Secretion machinery – MTs (+MAPs) and kinesin, neurofilaments, actin &
myosin V
Keratinocyte – skin epithelial cell
• Function: provides a continuously renewing, strong, waterproof surface to protect body
from environment
• Cell Specializations:
o Hemi-desmosomes – integrin attachment to basement membrane (with plectin &
IF’s)
▪ Signals – to make keratin
▪ Signals to divide – division machinery
▪ Survival signals – lose contact with ECM
• apoptosis, keratin release
o Desmosomes – cadherins & IF’s – for mechanical strength
Intestinal epithelial cell
• Functions
o Secretion of digestive enzymes
o Absorption of digested contents
o Keeps digestive juices away from bloodstream
• Cell Specializations:
o Hemi-desmosomes – integrin attachment to basement membrane (with plectins &
IF’s)
o Microvilli – actin, fimbrin, myosin I
o Tight Junctions – occludin and claudins - seal
Respiratory tract epithelial cell
• Function
o Capture particles & microorganisms
o moves mucous out of the body
o barrier between air and internal tissues
• Cell Specializations:
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Document Summary
Neuron: function, nerve impulses and formation and secretion of secretory vesicles, cell specializations, nerve impulses: na+/k+ pump, channels, etc, inc # of mitochondria atp, secretion machinery mts (+maps) and kinesin, neurofilaments, actin & myosin v. Keratinocyte skin epithelial cell: function: provides a continuously renewing, strong, waterproof surface to protect body from environment, cell specializations: Intestinal epithelial cell: functions, secretion of digestive enzymes, absorption of digested contents, keeps digestive juices away from bloodstream, cell specializations: If"s: microvilli actin, fimbrin, myosin i, tight junctions occludin and claudins - seal, hemi-desmosomes integrin attachment to basement membrane (with plectins & Respiratory tract epithelial cell: function, capture particles & microorganisms, moves mucous out of the body, barrier between air and internal tissues, cell specializations, hemi desmosomes integrin attachment to basement membrane (+ plectin & If"s: cilia mts and mt motor dynein (atpase, # mitochondria - atp, tight junctions occludin and claudins - seal.
