BIOB11H3 Lecture Notes - Lecture 24: Receptor Tyrosine Kinase, Signal Transduction, Protein Kinase A
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Lecture 22-24: signal transduction: g proteins, g-protein coupled receptors, lipid signalling, receptor tyrosine kinases & signal transduction. 3 basic communication strategies to respond to extracellular signalling molecules: a. ) >cell produces receptors for messengers it releases b. ) >cell produces messages for nearby cells c. ) endocrine. Extracellular messenger molecule is sent out by signalling cell (1st messenger) Ligand binds to speci c transmembrane receptors of target cell. Interaction on extracellular side causes a conformational change sending signal across membrane into the cytoplasm. 4a. ) receptor"s cytoplasmic domain signals for recruitment of signalling proteins. This 2nd messenger binds to a signalling protein to activate/deactivate it. Signalling protein is composed of multiple domains to allow for dynamic interactions with other partner proteins. *not always linear signalling, normally complex web of interactions. Delivered to circulatory system which distributes these signalling molecules to all cells in organism. Castrated roosters displayed abnormal social behaviour & did not develop secondary sex characteristics.