BIOC14H3 Lecture Notes - Lecture 8: Dopamine Receptor, Neuregulin, Haplotype
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Can conceptualize this as the degree to which the frequency of the allelic variant in the population interacts with the effect size (magnitude of the phenotypic change associated with the specific variant) of the variant. Bottom right : common variants at least (cid:887)% or more prevalent in the given population and those variants are the ones that are most commonly implicated in disease phenotypes by gwas. Can detect these variants with pretty good accuracy by sampling from a couple of hundred individuals in a population because the frequency is pretty high. Can detect phenotypic effects that are relatively modest or low in magnitude as long as you have effects that are relatively common in a population because this is a statistical question. The more individuals you have with the variant in the population the smaller the effect size will be and you can still detect it.
