BIOC17H3 Lecture Notes - Lecture 7: Staphylokinase, Immunosuppression, Necrotizing Fasciitis
5 Oct 2017
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It is covalently bond to the phospholipids or lps. Staphylococcus: capsule are found in both gram-positive and negative bacteria, ex: streptococcus mutans capsule is composed of dextrans (linear polymer of glucose), which is part of our flora and produces cavities. Eating fructose feeds mutans by producing capsules: ex: streptococcus pyogens capsule is composed of hyaluronic acid, which is flesh eating, this helps the bacteria from being safe from host immune system. The capsulated stain can grow in lungs but the uncapsulated one cannot as it gets phagocytosed by host cells: sline layer: glycocalyx formed by material loosely adhered to the cell wall of the cell. Immune system cannot adhere to capsule bacteria: protection from host inflammatory response inhibition of phagocytosis and complement activation. Slide 15: normally, pathogen are recognized and defences are activated (by damaged tissue releasing histamines which increases capillaries flow). This allows phagocytes to capture and destroy bacteria.
