BIOC32H3 Lecture Notes - Lecture 19: Pancreas, Thyroid, Adrenal Gland

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9 Jan 2015
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Endocrine glands/cells- hormones secreted directly into blood stream by specialized cells. Can be transported to distant targets via blood stream. Does not secrete hormones: exo [outside] - secretes out. Hormones effects last minutes, hours, days, weeks, and months. Regulation of internal environment e. g temperature, water balance, ion movement. Acts on multiple tissues; effect on tissue depends on type of tissue and stage of development e. g embryo, infant, teenager, adult, elderly. Hormones = degraded to inactive metabolites by enzymes (often in the liver and kidneys) excreted in urine and bile (from liver) Half life: the amount of time required to decrease the concentration of hormone in the circulation by half. Three chemical classes of hormones: amine hormones, peptide hormones, steroid hormones, amine hormones. Derived from tryptophan (e. g 5ht) or tyrosine (dopamine, adrenaline, noradrenaline) Small molecules -> short half life; half life of seconds -> needs to be continuously secreted for long duration of action e. g melatonin and thyroid hormone.

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