BIOC39H3 Lecture Notes - Lecture 2: Immunity (Medical), Bloodborne, African Trypanosomiasis
6 Dec 2017
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Document Summary
The etiology, pathogenesis and clinical manifestations of many diseases are rooted in the immune response. Autoi(cid:373)(cid:373)u(cid:374)e diseases (cid:894)o(cid:374) the rise i(cid:374) wester(cid:374) societ(cid:455)(cid:895): addiso(cid:374)s, celiac, croh(cid:374)"s. Immunodeficiency (genetic deficiencies in the immune response): x-linked agammaglobulinemia. Graft vs host disease challenge to transplantation. Therapeutic antibodies are the highest earning category of biological drug. ~30 approved antibodies treat several major diseases including autoimmune, cardiovascular and infectious diseases, cancer and inflammation. Immune system- the tissues, cells and molecules mediating defense of the body against infectious agents. Immunization- the deliberate provocation of an immune response. Jenner 1796 small pox - edward jenner, vet- milk maids who milked cows developed mild disease from cow pox virus get boils on hands but otherwise it was mild. He postulated that these milk maids were resistant to small pox and. Von behring kitasato 1890 antibodies- around the same time they discovered an antitoxin to diphtheria and tetanus. The immune system is challenged by varied pathogens.
