BIOC39H3 Lecture Notes - Lecture 23: Mhc Class Ii, Hematopoietic Stem Cell Transplantation, Alloimmunity
8 Apr 2015
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Transplantation antigens/mhc antigens: highly polymorphic hla class i and ii molecules that differs in each person. Immune responses against transplanted tissues or organs are caused by genetic differences between donor and recipient, caused by alloantigens. Alloantigens: antigens which vary between members of the same species. Immunogenitics: a subfield of immunology devotes to the genetics of alloantigens. Transplantation of tissue from one site to another on the same person. The type of alloreaction in transplantation depends on the type of tissue transplanted. Recipient-derived antibodies and effector t cells attack transplant. Usually occurs with transplantation of organs (kidney, heart) Donor-derived mature and memory t cells attack recipient"s tissues. Occurs with bone marrow transplant, where the recipient"s immune system is destroyed and replaced by the cells in the bone marrow graft. Human erythrocytes lack hla i and hla ii: less genetic barrier for transplanting. O a, and b blood groups all have structurally different antigens.
