BIOC39H3 Lecture Notes - Lecture 4: Immunoglobulin Heavy Chain, Adaptive Immune System, B-Cell Receptor

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1: structure of an antibody: ig domain and hypervariable regions, antibody isotypes, epitopes what they are and how they are recognized, affinity vs avidity, good antigens make strong antibodies. Immune response specifically targeted against a particular pathogen: some pathogen-specific cells are long-lived membrane cells = immunological memory. Only a feature of the adaptive immune system: capacity to recognize any new target - mechanism to check rapidly evolving microorganisms. Recognition mechanisms of innate vs. adaptive immune system: Recognize conserved pamps (pathogen associated molecular pattern) or recognize altered self in terms of nk cells. Fixed repertoire of cell-surface and soluble molecules -what they are able to recognize. Almost infinite repertoire of recognition of different pathogens. Receptors germline encoded (inherited from one generation to the next) Recognition mechanism is a single molecular type - different specificities but the backbone is the same molecule (different for t & b cells) Secreted antibody is of the same specificity as membrane ig (bcr)

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