BIOC39H3 Lecture Notes - Lecture 6: Affinity Maturation, Immunoglobulin M, Primary And Secondary Antibodies
26 Mar 2020
School
Department
Course
Professor
Document Summary
Antibody effector functions: 3 main effector functions: Antibody isotypes differ in structure and function: 4 subclasses of igg: igg1, igg2, igg3, igg4, 2 subclasses of iga: iga1, iga2 - important within mucosal tissue first antibody isotype that secreted. ~185kda in serum largely thought of it as a membrane receptor. if its deleted in a mouse model, then the mouse would still be okay. its expressed 10-fold higher than igm: not much function in the serum. Iga: fairly high serum concentration ~3mg/ml, 160kda as monomer, heavily glycosylated, some serum iga found as dimers with j chain. Ige: normally very low serum levels (10-50 ng/ml). Except in allergic individuals, when its elevated: ~188kda in serum, heavily glycosylated, elevated in allergic individuals (to microgram/ml) Cytokines released by t cells influence isotype switching. Lfa-1 and icam-1 are allowing the two cells to hold onto each other. this creates a very tight interface within the.
