BIOC39H3 Lecture Notes - Lecture 2: Cfu-Gemm, Hematopoietic Stem Cell, Lymphopoiesis

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Make up the cells of the immune system along with tissue cells related to them. Encompasses various cell types with different functions (11 main cell types) Continuously generated by the body in the development process known as hematopoiesis. Derived from pluripotent hematopoietic stem cells: progenitor of leukocytes, also gives rise to erythrocytes (red blood cells)and megakaryocytes (source of platelets, all of the above cells are collectively called hematopoietic cells. Early embryo: blood cells are first produced in the yolk sac and later in the fetal liver. 3rd 7th month of fetal life: the spleen is the major site for hematopoiesis. 5th month till birth: during this time as bones develop hematopoiesis begins to shift to the bone marrow. Adults: hematopoiesis takes place in bone marrow of skull, ribs, sternum, vertebral column, pelvis, and fermus, red blood cells are short-lived so they are continually renewed hematopoiesis is active throughout life. Self-renewal: hsc can divide to give further hsc.

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