BIOA01H3 Lecture Notes - Lecture 28: Sickle-Cell Disease, Red Blood Cell, Familial Hypercholesterolemia

• School: UTSC
• Department: Biological Sciences
• Course: BIOA01H3
• Professor: Monica Sauer

Document Summary

Definition: incomplete dominance occurs when the effects of recessive alleles can be detected to some extent in heterozygote. It"s doesn"t completely appear as the dominant allele, it"s a trait in between. Example: crossing a red flower and a white flower can give you a pink colour. See slide 2-3 for example (the exponent letter is very important) Homozygote recessive has sickle-cell disease (you have sever anemia) Heterozygote (carrier for the sickle-cell disease) has milder sickle-cell trait (only shows some traits/symptoms) Familial hypercholesterolemia (high cholesterol no matter how good is your diet) Heterozygote has mild form of disease (carrier less severe form of the disease) Heterozygote has no symptoms but has detectable biochemical effects (differences at the enzymatic activity) A mutation in the gene coding for beta hemoglobin. It"s a point mutation (one amino acid substitution) that reduces the ability of the red blood cells to carry oxygen.