BIOB10Y3

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Department
Biological Sciences
Course
BIOB10H3
Professor
Tanya Da Sylva
Semester
Summer

Description
mRNA stability and microRNAsmRNA stabilityLifetimes of eukaryotic mRNA varyPolyA tail length may play a rolePolyA tail reduced as mRNA resides in cytoplasmCertain destabilizing proteins in the 3 UTR may affect the rate of polyA tail shorteningWhen the tail is about 30 A residuesmRNA stabilityOnce 3 tail is removed message is decappedand degraded from 5 endDeadenylation decapping and 5 3 degradation occur within small transient cytoplasmic granules
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