BIOB11H3 Lecture Notes - Lecture 24: Bcl-2-Associated X Protein, Apoptosis, Phagocytosis
Document Summary
Thursday, july 28: mapk activated ultimately by phosphorylation cascade. Slide 6: mkp turns off map, tf is phosphorylated inside the nucleus (picture shows outside) Slide 17: eventually cell would be recognized as being compromised and phagocytosis would get rid of it. Slide 18: t cell recognizes foreign cell and induces apoptosis. Slide 19: extrinsic pathway, extracellular domain where ligand can bind, procaspase 8 precursor form of caspase, two procaspase molecs is cleaving each other. Intrinsic pathway: bax becomes activated forms membrane channel in mitochondria, when membrane channel forms mito material leaks out (cytochrome) Slide 23: can"t make mac w/o bax apoptosis cannot be triggered.
