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Lecture 9

BIOB32H3 Lecture 9: Lecture 9

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University of Toronto Scarborough
Biological Sciences
Kenneth Welch

BIOB32 – Lecture 9 - There nerst equation comes from from two different equation 1) the amount of work it takes to move an ion against its electrical gradient 2) one that moves against the concentration gradient the number of ions that are flexing from the outside to the inside, there is an equal number of ions flexing from the inside to the outside, when the ionic species is at equilibrium - the inside of the membrane is slightly negative relative to the outside for the frog muscle cell, if you compare the measure that you obtained from the calculation from the actual measure, you will see a difference and this means that potassium is not the only thing that plays a role here -> there is a lot of calcium that is attached as cofactors to the various cells - membrane is not only permeable to calcium, it is also permeate to otr - the permeability to these ions are different - chloride is less permeable, this is due to the channels that sit there to allow the ion species to go through in the cell at rest , so there are resting potassium channels that sit open to allow potassium to pass through, there is a lot of sodium channel, but there is only a few chlorine ions - the difference between sodium and potassium relative to chlorine is that they are positively charged - because the value for chlorine are very very close to 0 we can just drop it and potassium and sodium are the ones that play a big role - if the potassium concentration is relative high, it will have a high drive into the cell and it will have a huge drive into the cell - the potassium channels are often delays, they are activated on time but it takes them a short amount of time before they function You can inject currents in the system and see what happens in the membrane potential inside - the current will be negatively changed and it will attach to the pos
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