Lecture 7

24 Pages
Unlock Document

University of Toronto Scarborough
Biological Sciences
Ingrid L.Stefanovic

‡ Type of neurotransmitter released from axon bouton defines the type of neuron e.g Dopaminergic neurons release the neurotrasmitter (NT) _dopamine_(DA) _(nor)adrenergic_ neurons release the NT noradrenaline (norepinephrine) Cholinergic neurons release _acetylcholine________________ ‡ NT can be released into the blood stream to causes effects e.g _adrenaline_ ‡ Different types of R are located in different regions of the body ‡ GABAergic and glutamatergic Rs are found _all over the brain________ ‡ High levels of dopaminergic Rs are found high in the _areas of the brain that control of moods, personality, motor functions ‡ Cholinergic R are found in _skeletal muscle, brain regions involved in motor Control, heart___________________________ 1 ‡ Adrenergic R located in __hearwww.notesolution.comain____________________ Signalling Molecules downstream of GPCR Neurotransmitter Receptor Amplifying enzymes Second messengers Response 2 www.notesolution.com Figure 6-7 and 6.9 Signalling Molecules downstream of GPCR 1. The G protein-coupled adenylyl cylase - cAMP system STIMULATION =Gs NT GPCR Amplifying enzyme EC membrane Used for receptors of GP IC androgenic : b1 +b2+b3 or Second messengers Dopaminergic: d1 kinases intracellular proteins 3 www.notesolution.com www.notesolution.com Signalling Molecules downstream of GPCR 2. The GP-coupled phospholipase ± DAG and IP3 system NT Amplifying Second EC GPCR enzyme messengers kinasesmembrane IC endoplasmic reticulum intracellular proteins 3 Different signalling Used by receptors: molecules: 1 DAG Adrenergic: a2 2 IP3 3 Ca2+ 5 www.notesolution.com Coupling of receptors to signalling molecules Adrenergic Rs Adrenaline/Noradrenaline ‡ -1, -2, -3: - G protein = Gs , - Activates adenylyl cylase - G protein = Gq - Increases cAMP - Excitatory cellular responses - Activates PLC - Increases DAG, IP3, Ca2+ Dopaminergic Rs - Dopamine ,2: - G protein = Gi ‡ D1: - Inhibits adenylyl cyclase - G protein = Gs - Decreases cAMP - Activates adenylyl cylase - Inhibitory cellular responses - Increases cAMP - Excitatory cellular responses 6 Summary ‡ Synthesis, release and catabolism of different neurotransmitters ‡ Types of neurotransmitters and receptors - Amine Receptors - Amino Acid Receptors - Acetylcholine Receptors ‡ Different locations of receptor subtypes and their function ‡ Types of downstream signalling molecules associated with receptor subtypes - amplifying enzymes - second messengers - downstream effects ‡ Functions of neurotransmitter receptors ‡ Receptors as targets for therapeutics and drug abuse 7 www.notesolution.com Lecture 7: Neuronal Integration 5th October 8 Lecture Outline ‡ Integration of neuronal information - Divergence and convergence - Spatial and temporal summation of graded potentials - Presynaptic and postsynaptic modulation - Learning and memory ‡ Axon guidance in the developing brain ‡ Acute and chronic neuronal damage 9 Neurons communicate via a combination of divergent and convergent signals Convergence collates signals Divergence: one neuron connects with many neurons Figure 8.25 10 Neurons communicate via a combination of divergent and convergent signals 11 Figure 8.25 www.notesolution.com Spatial summation of graded potentials that depolarise the membrane minature excitatory postsynaptic potentials (mEPSPs) 3 depolarising GPs (mEPSPs) mEPSP + mEPSP + mEPSP = Threshold ‡Summation of GP triggered in different location
More Less

Related notes for BIOD27H3

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.