EESA10H3 Lecture Notes - Lecture 5: Arsenic Pentoxide, Immunosuppression, Silt
12 Feb 2017
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Toxicity: class b > borderline > class a. Mechanisms of toxicity: blocking essential functional groups such as proteins or enzymes, proteins can not carry anything, displace other metals (class b, borderline, modifying the active conformation of biomolecules (class b) Can develop multiple tolerance - cu, pb, zn, cd. Bioavailability of metals: species of the metal - free ions (charged ions zn+2 are more bioavailable than zno , neutral species may be bioavailable, important in complexes, ph of solution, redox potential of solution. First discovered in minamata city in japan in 1956. It was caused by the release of methylmercury in the industrial wastewater from the chisso corporation"s chemical factory, which continued from 1932 to 1968. This highly toxic chemical bioaccumulation in shellfish and fish in minamata bay and the shiranui sea, which when eaten by the local population resulted in mercury poisoning. Cat, dog, pig and human deaths continued over more than 30 years.
