EESA10H3 Lecture Notes - Lecture 4: Polychlorinated Biphenyl, Miscarriage, Carcinoma
1 Feb 2018
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Endocrine disrupters: direct effects: bind to hormone receptors, alter appearance of genes, changes in level of produced protein. Indirect effects: altering hormone production, altering hormone transport, altering hormone metabolism: fetus more sensitive than adults. Des (dietheylstilbesteol: synthetic estrogen used by physicians to prevent spontaneous abortion, administered for early pregnancy until 35 weeks, >1million women took it between 1960-70, daughters whose mothers took des have increased incidents of. Endocrine disrupters- health implications: feminization of males, abnormal sexual behavior, birth defects, altered time to puberty, cancer of mammary glands or testes, thyroid dysfunction. Endocrine disrupters- neurobehavioral implications: prenatal and early postnatal exposures, pbc"s (cid:894)poly(cid:272)hlori(cid:374)ated (cid:271)iphe(cid:374)yls(cid:895) Lec 4 jan 30: quantity of chemicals accumulated in the body. Not possible to defect if present in very low concentrations. Dioxins: dioxins have no commercial usefulness by themselves, formed during. Combustion process such as waste incineration, forest fires and backyard trash burning. Cause cancer in lab animals and humans, mechanism is not known.
