EESA10H3 Lecture Notes - Lecture 4: Biomonitoring, Pituitary Gland, Semen Analysis
20 Apr 2016
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Pineal, pituitary gland, parathyroid, thyroid, thymus, adrenal gland, pancreases, ovary, testicles. Direct effect: bind to hormone receptor alters the appearance of some genes and change in the level of produce protein. Des: diethylstilbesteol; synthetic estrogen used by physician to prevent spontaneous abortion, early pregnancy until 35 weeks, Daughters who mother took it had increase incident of reproductive organ dysfunction, abnormal pregnancies, reduction in fertility, immune system disorder, carcinoma. Health implication: feminization of males, abnormal sexual behaviour, birth defect, altered time to puberty, thyroid dysfunction, cancer of mammary gland or testes. Pcbs: impared learning in nonhuman primate, delayed psychomotor development, distractivility, poor iq test. Not stable over time, not distributed homogeneously in a body, not possible to detect if present in very low concentration, biomonitoring- normal levels. Dioxins, ddt, phthalate plasticizers and bisphenol a o. Dioxins: no commercial usefulness by themselves, formed during o. Combustion processes such as waste incineration, forest fire and backyard trash burning.
