HISC45H3 Lecture Notes - Lecture 1: Genetic Linkage, Synteny, Genetic Distance
Document Summary
1 map unit is the genetic distance between two syntenic genes that generates 1% recombinant types. Interference is the phenomenon that occurs when the occurrence of the first crossover affects the probability of another crossover on the same chromosome occurring. Positive interference (common) means that one crossover reduces the probability of a second crossover event occurring, nearby along the length of the chromosome. Negative interference (rare) means that the occurrence of one crossover seems to promote the occurrence of another nearby. Calculate interference as (1 cc) x 100 = % interference cc = coefficient of coincidence = cc= observed # double crossovers / # crossovers predicted (if there is no interference) If he predicted number of dc recombinant types = 34; And he observed number dc recombinant types was 22 cc = observed # dc recombinant types /predicted # dc recombinant types =
