1494 -- king charles viii (france) invaded italy - outbreak. 1530 giovanni de vigo (personal surgeon to pope julius ii) - man with an unclean woman - blue black or sometimes whitish. Pamphlet on syphilis - 4 editions -- 1495 - a fine treatise on the origin of the. Girolamo fracas toro (1478-1553) - venetian physician. Shepherd boy named syphilus insulted god and punished with horrible disease. Names: morbas gallicus (late 15th century europe), the french disease (italy and. Germany), italian disease (france), spanish disease (dutch), polish disease (russians), christian disease (turks), british disease (tahiti), great pox (distinguish from small pox), lues or lues verenea (veneral plague), ____________ John hunter (1728-1793) -- injected gonorrhoea into body and developed signs of syphilis and established that the two were the same. Philippe ricord (1799-1889) -- gonorrhoea and syphilis are different. Rudolph virchow (1821-1902) -- syphilis was spread through the body by blood. Extremely fragile spirochete surviving only briefly outside the host.