PSYB51H3 Lecture 4: Lecture 4 Protein transport through the endomembrane system
Document Summary
The vesicle: a membrane enclosed dynamic cellular organelle that is involved in the selective transport of proteins/materials to other compartments. A recipient compartment: vesicle will fuse with this compartment and deliver its contents. Buddi(cid:374)g (cid:448)esi(cid:272)les ha(cid:448)e a (cid:862)coat(cid:863) of solu(cid:271)le (cid:894)(cid:272)(cid:455)tosoli(cid:272)(cid:895) protei(cid:374)s that asse(cid:373)(cid:271)le o(cid:374) the (cid:373)e(cid:373)(cid:271)ra(cid:374)es of the donor compartment. Can mechanically force the membrane to curve and form a budding vesicle. Can bind to specific transmembrane proteins - receptors - that in turn bind specific soluble components/proteins cargo - to be recruited into the budding vesicle. Coat proteins assemble on the cytosolic face of membranes and induce vesicle budding. Components include: secretory, lysosomal, and membrane proteins to be transported and machinery required to target and dock the vesicle to the correct acceptor membrane. Vesi(cid:272)le (cid:272)oats (cid:449)ere dis(cid:272)o(cid:448)ered i(cid:374) em as a (cid:862)fuzz(cid:455)(cid:863) ele(cid:272)tro(cid:374) de(cid:374)se outer la(cid:455)er. Coated buds pinch off into coated vesicle. Vesicles can have different types of protein coats:
