BCH210H1 Lecture Notes - Lecture 23: Fischer Projection, Ketose, Hemiacetal

• School: UTSG
• Department: Biochemical Engineering and Applied Chemistry
• Course: BCH210H1
• Professor: Reinhart Reithmeier

Document Summary

Lecture 1 energy, structural use, in dna/rna, used for recognition: most abundant class of mol"c, d-sugars are bio"y relevant in bacterial cell walls, agar/agarose, glycolipids/proteins, lectins = recognition, glyco for folding (properly folded or not?) Abo blood group antigens: a, ab, o, have sugars on cell membrane are the antigens, recognized by antibodies. # of linear stereoisomers = 2 x (x = number of chiral carbons) Optical activity: d & l orient"n at ea. chiral c enantiomers non-superimposable mirror images, will polarize light differently are optically active (+, d) rotate right (-, l) rotate left. Carbohydrate cyclization aldehyde & hydroxyl groups are reactive intramol"c rxn nucleophilic attack 5 or 6 member ring furanose: 5-member ring: pyranose: 6-member ring, hemiacetal: aldehyde deriv, hemiketal: ketone deriv. Oh attacks c=o must be in water solution, oh release h, c-o accept h. Glucose cyclization: oh on c5 attacks c=o of aldehyde.