BIO120H1 Lecture Notes - Iron Lung, Poliomyelitis, Cytosol
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BIO120H1 Full Course Notes
Verified Note
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Document Summary
Naked icosahedral capsids because only contains a capsid not an envelope. All genes translated into a huge protein (atypical of eukaryote) Death of motor neurons in the spinal cord which leads to paralysis. Serotypes are different antigens on the outside of a virion. This is a pathogen that has co-evolved with us. It has extra cellular domains that are disulphide linked. Unique to virus: viral proteins insert into the host cell membrane, possibly making a pore through which the rna genome is injected. Ires present in the 5" non-coding region of the viral rna: multiple stem-loop structures. These rnas do not rely on the 5" methyl cap, its own rna do not have the methyl cap. Cap-dependent translation (which our cells normally do), the virus is going to find a way to stop this from happening. The virus is going to target a host factor called eif host complex and destroy it.
