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Lecture

Notes taken during lecture


Department
Biology
Course Code
BIO120H1
Professor
Jean Jiang Nash

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ATP Binding Cassette ABC
MDR, CFTR disease related transporters
4 multipass transmembrane protein two of each the cup forms a pore
Eukaryotes, almost all are exporters; while prokaryotes, importers and exporters exist
Dimerization of ATP-binding domains
oTwo ATP molecules, one for each ABC form protein protein complex,
cauising conformational change in the protein thus opening on otherside of
the membrane
Dissociation
Conformational changes in transmembrane domains
Bacteria harmful to us because they export this Lipid A
Conformational change ABD domains closer together
Binding pocket also changes conformation
Video is an export example
5 sequester toxins removed by leaf shedding
Vacuole of leaf cells get inflated with toxins, and get rid of leaf to lose toxins
In animals, exporting waste out of cells
6 MDR1-possesing cells can survive chemotherapy by exporting it out of the cytosol, so the
few that survives
Selecting for cells that survive
Chemotherapy does NOT cause tumour regrowth
Also has normal function in normal body cells
CFTR cystic fibrosis caused by calcium levels
No details needed n
7 A) Transporter proteins ALL change conformation as they transport molecule across
membrane
Channels are pores, can open and close, but this is not conformation change
8 hydrophilic pore
*no comformational change*
Size of molecule, shape of molecule, charge of molecule thus pore is selective, a filter
selecting
Weaker interactions with solute
Faster transport by channels
Several molecules pass through when open
9 - human bodies contain channels gated by heat
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