Notes taken during lecture

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19 Jan 2011
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ATP Binding Cassette ABC
MDR, CFTR disease related transporters
4 multipass transmembrane protein two of each the cup forms a pore
Eukaryotes, almost all are exporters; while prokaryotes, importers and exporters exist
Dimerization of ATP-binding domains
oTwo ATP molecules, one for each ABC form protein protein complex,
cauising conformational change in the protein thus opening on otherside of
the membrane
Dissociation
Conformational changes in transmembrane domains
Bacteria harmful to us because they export this Lipid A
Conformational change ABD domains closer together
Binding pocket also changes conformation
Video is an export example
5 sequester toxins removed by leaf shedding
Vacuole of leaf cells get inflated with toxins, and get rid of leaf to lose toxins
In animals, exporting waste out of cells
6 MDR1-possesing cells can survive chemotherapy by exporting it out of the cytosol, so the
few that survives
Selecting for cells that survive
Chemotherapy does NOT cause tumour regrowth
Also has normal function in normal body cells
CFTR cystic fibrosis caused by calcium levels
No details needed n
7 A) Transporter proteins ALL change conformation as they transport molecule across
membrane
Channels are pores, can open and close, but this is not conformation change
8 hydrophilic pore
*no comformational change*
Size of molecule, shape of molecule, charge of molecule thus pore is selective, a filter
selecting
Weaker interactions with solute
Faster transport by channels
Several molecules pass through when open
9 - human bodies contain channels gated by heat
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Document Summary

4 multipass transmembrane protein two of each the cup forms a pore. Eukaryotes, almost all are exporters; while prokaryotes, importers and exporters exist. dimerization of atp-binding domains: two atp molecules, one for each abc form protein protein complex, cauising conformational change in the protein thus opening on otherside of the membrane. Bacteria harmful to us because they export this lipid a. 5 sequester toxins removed by leaf shedding . Vacuole of leaf cells get inflated with toxins, and get rid of leaf to lose toxins. 6 mdr1-possesing cells can survive chemotherapy by exporting it out of the cytosol, so the few that survives. Also has normal function in normal body cells. Cftr cystic fibrosis caused by calcium levels. 7 a) transporter proteins all change conformation as they transport molecule across membrane. Channels are pores, can open and close, but this is not conformation change.

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