BIO120H1 Lecture Notes - Lecture 12: Mitogen-Activated Protein Kinase Kinase, Osmotic Concentration, Exocytosis

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tealwildebeest741

18 Apr 2011

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S specificity conferred by using different kinases but some initial kinases are shared, e. g. map-kkk a. S scaffold proteins contain multiple binding domains to bind to signalling proteins, it holds components of map k signalling cascade so they can t drift off to activate other pathways, domains on the scaffold can also act as a kinase. S once map is activated, it will leave the scaffold and move into the nucleus to p-ate transcription factors that mediate the transcription of genes: plants (receptor ser/thr kinases, histidine kinase associated receptor) S activated by jak/stat pathway, erythropoietin binds to and dimerizes receptors, activating jak2 which p-ate receptor and recruits and p-ates stat5, activating the transcription of genes required for red blood cell development and function. S experiment: mouse development epor gene knockout mouse embryos, die due to lack of o2 has red fetal liver showing erythrocyte production transport to fetal organs, wildtype.

Related Questions

Why is the kinase so important in a receptor tyrosinekinase?

Tyrosine kinases activate synapses, triggering cellularresponses.

Tyrosine kinase is the signal that the receptor binds.

Kinases transfer phosphates, phosphorylating the receptor.

The tyrosine kinase domains are active in their monomericstates.

The tyrosine kinase uses guanosine triphosphate to becomeactivated.

redmouse91

Can someone please help me with the 2 questions below! I'm notunderstanding at all and can you explain how you got your answer soI can understand. Thank you in advance! :)

Epidermal Growth Factor is a protein that binds its receptorwith high affinity (low Kd). Choose the most likely order of eventsfor what ensues:

A) G protein activation> tyrosine kinase activity>transcription factors active> map kinase activation and signalamplification
B) G protein activation and signal amplification > mapkinase activation >transcription factors active>tyrosinekinase activity
C) tyrosine kinase activity>G protein activation> mapkinase activation and signal amplification>transcription factorsactive
D) tyrosine kinase activity>Gprotein activation> phosphatase activation> secondmessengers>map kinase activation >transcription factorsactive

2. Epidermal Growth Factor (EGF) levels eventually dissipate andthe cellular response (gene transcription and translation) stops.Which of the following is not a possible reason for a cancer cellto have an inappropriate EGF pathway response:

A) mutation in an EGF receptor gene

B) mutation in a ras gene

C) mutation in a gene coding for a kinase

D) mutation in a gene coding for a second messenger

ceruleanpig915

There are at least 600 genes in human genome encodingprotein kinases involved in signal transduction pathways. Theseprotein kinases are catalogued into four groups, and each isactivated by a different factor. What are these four groups ofprotein kinases and their corresponding activatingfactor?