BIO120H1 Lecture Notes - Lecture 12: Mitogen-Activated Protein Kinase Kinase, Osmotic Concentration, Exocytosis

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S specificity conferred by using different kinases but some initial kinases are shared, e. g. map-kkk a. S scaffold proteins contain multiple binding domains to bind to signalling proteins, it holds components of map k signalling cascade so they can t drift off to activate other pathways, domains on the scaffold can also act as a kinase. S once map is activated, it will leave the scaffold and move into the nucleus to p-ate transcription factors that mediate the transcription of genes: plants (receptor ser/thr kinases, histidine kinase associated receptor) S activated by jak/stat pathway, erythropoietin binds to and dimerizes receptors, activating jak2 which p-ate receptor and recruits and p-ates stat5, activating the transcription of genes required for red blood cell development and function. S experiment: mouse development epor gene knockout mouse embryos, die due to lack of o2 has red fetal liver showing erythrocyte production transport to fetal organs, wildtype.

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