BIO130H1 Lecture Notes - Lecture 18: Synthetic Membrane, Oligosaccharide, Atp Synthase
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BIO130H1 Full Course Notes
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The path of a transmembrane: (this protein will remain a part of the plasma membrane: cytosol er (co-translational translocation) Translation begins in the cytosol (the mrna arrives from the nucleus) and the protein ends up in the er: the protein is translocated into the er. This requires a signal sequence which will target it to the er. This protein will have at least one transmembrane domain. Hydrophobic transmembrane domain: single pass one single sequence that"s hydrophobic. That"s the transmembrane domain, will span the bilayer as an. The translocator will open a pore and allow the entry of the polypeptide. The signal sequence: directs proteins to the er. The translocator pore has more + charge towards the lumen: ensures that the hydrophobic sequence has more. Amino terminus translated first: the more negatively charged will end up in the er lumen, this directs the.