BIO230H1 Lecture Notes - Lecture 10: Cell Cycle Checkpoint, Cyclin E, Cyclin B

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12 Dec 2017
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BIO230H1 Full Course Notes
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To understand normal cell biology and disease we must understand the molecular machinery that functions inside cells to control their shapes, functions, interactions and numbers. Controlling cell numbers critical for how tissues built and maintained. Also need to control cell numbers with cancer development. [2] cell has to split duplicated contents in half. Need fidelity with which the cell duplicates and segregates its genome. Genome = passed on from fertilized egg to all cells of body. As cells divide during development, mistakes have to be avoided. Do(cid:374)"t (cid:449)a(cid:374)t to lose ge(cid:374)es duri(cid:374)g di(cid:448)isio(cid:374) Four main phases of the eukaryotic cell cycle. Starting between green at light blue: this is just after division, and daughter cell is born. All of components of cell (proteins, organelles) except for dna duplicated. A(cid:374)y orga(cid:374)elles that ha(cid:448)e(cid:374)"t (cid:271)ee(cid:374) dupli(cid:272)ated already are dupli(cid:272)ated. If problem stops cell cycle at that stage. Multicellular organism: physiological signals that tell cell whether or not to divide.

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