BCH210H1 Lecture Notes - Lecture 19: Cell Membrane, Pyruvic Acid, Thrombus

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BCH210H1 Full Course Notes
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BCH210H1 Full Course Notes
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We can manipulate them, we can inhibit the gene product. Clles have a regulatory mechanism to control if its on or off. This enzyme is limited by its substrate availability, and its substrate is arachidonic acid. Arachidonic acid is a 20:4 polyunstaurated fatty acid. In the prese(cid:374)(cid:272)e of this a(cid:272)id, (cid:272)(cid:455)(cid:272)loo(cid:454)(cid:455)ge(cid:374)ase takes it a(cid:374)d o(cid:454)(cid:455)ge(cid:374)ases it. If (cid:449)e are health(cid:455), (cid:449)e do(cid:374)"t ha(cid:448)e this a(cid:272)id a(cid:374)d (cid:272)(cid:455)(cid:272)loo(cid:454)(cid:455)ge(cid:374)ase is(cid:374)"t arou(cid:374)d. if (cid:449)e ha(cid:448)e a(cid:374) i(cid:374)jur(cid:455) like a heart atta(cid:272)k or a stroke, this injury is called a wounding response. With this type of injury, the subrate becomes available. Its available because phospholipase a2 becomes available and it takes a phospholipid in the plasma membrane, it cleaves off the faattty acid in the backbone producing arachidonic acid. It cleaves off the ftty acid tail at position 2. Eicosanoids are precursors for prostaglandins, leukotrienes and thromboenes, which can cause thrombus formation, vasoconstriction and pain, fever.

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