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University of Toronto St. George
Jean Jiang Nash

th LECTURE 16 March 8 Anchoring junctions continued. SELECTINS the next type of anchoring junctions Type of lectin Lectins are carbohydrate-binding domains To oligosaccharides on other cells Not catenins in this case dont need to know the actual name Also clustered giving interaction high avidity strong Velcro interaction Blood vessel Cells secrete yellow stuff, which cells stick to Epithelium lined blood vessel = endothelium Rolling on cells because of infection o Secreting signal received by endothelial cells in nearby blood vessel, which begin to express p-selectin which is now sticking out of membrane, and start to attract or stick to the cells, Rolling is selectin-dependent Sticking mechanism based on integrins Weak adhesion and rolling on selectins strong adhesion and integrins Cells will move in between endothelial cells and Extravization ? DRAW TABLE to summarize Other anchoring junctions Immunoglobulin superfamily o These proteins have immunoglobulin domain o Immunoglobulin = antibody o Antibody made up of those Ig domains o CD4 = ex. of immunoglobulin superfamily protein o Multiple Ig-like extracellular domains o Mediate calcium-independent, homophilic or heterophilic receptor interactions DESMOSOMES Like adherence junction Like cadherin like proteins outside cell but inside cell, linked to intermediate filaments, instead of actin Bind intermediate filaments Adaptor proteins linking adhesion complex to intermediate filaments not catenins, different proteins Strengthening tissues
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