Class Notes (809,509)
Canada (493,754)
Biology (2,220)
BIO230H1 (243)
Lecture 9

BIO230H1 Lecture 9 Notes.docx

2 Pages
Unlock Document

University of Toronto St. George
Jennifer Harris

BIO230H1 Lecture 9 Notes 921-931 Signaling Through Enzyme Coupled Cell Surface Receptors  Enzyme coupled receptors are transmembrane proteins with ligand- binding domain Activated Receptor Tyrosine Kinases (RTKs) Phosphorlyate Themselves  Many extracellular signals can be determined by receptor tyrosine kinases  RTKs can autophosphorylate  Dimerization can occur Phosphorylated Tyrosine on RTKs Serve as Docking Sites for Intracellular Signaling Proteins  Cross phosphorylation can occur; first phosphorylating the kinase domain then the kinase domain creates a docking site  RTK activate the signaling molecules Proteins with SH2 Domains Binds to Phosphorylated Tyrosine  Interaction domains: docked proteins  SH2 domains were bound Ras Belongs to a Large Superfamily of Monomeric GTPase  Ras superfamily small GTPase  Ras can cycle between GTP and GDP RTKs Activate Via Adaptors and GEFs Evidence from the Developing Drosophila Eye  Ommatidia unit: photoreceptor cells  R7 cell UV light detection  Bride of sevenless (Boss): encodes for a ligand Ras Activates a MAP  Ras can help activate activity through phosphorylation  Scaffold molecules help
More Less

Related notes for BIO230H1

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.