CSB327H1 Lecture Notes - Lecture 6: Microfibril, Covalent Bond, Chondrocyte
10 Oct 2012
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Document Summary
Organization of the kidney: nephron is the basic and functional unit of the kidney. There are one million nephrons in each kidney. Contains a glomerular (bowman"s) capsule that surrounds a glomerulus (group of capillaries) Two specialized cells associated with the glomerulus. Inside the glomerular capillaries is an endothelium (endothelial cells: cells are fenestrated to allow direct contact between the contents of the blood and the gbm, the gbm is exposed to the contents of the blood. Outside the glomerular capillaries are podocytes (visceral epithelial cells: cells have feet-like processes, adjacent podocytes are bridged by filtration slits, which as act as a physical barrier to prevent diffusion of serum proteins into the bowman"s capsule. Filtration slits impart a size selection (>30 kda) Both contribute to making the glomerular basement membrane. The gbm provides support and barrier functions to the glomerulus. Organized into three distinct layers: lamnina rara externa (facing podocytes, middle lamina densa (thickest)
