CSB346H1 Lecture Notes - Lecture 7: Motor Neuron, Vacuum Cleaner, Non-Rapid Eye Movement Sleep

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB346H1
• Professor: John Peever

Document Summary

Co2 levels rise (don"t expel as much co2 as you do when awake. In an experiment, an individual inspiratory neuron discharges vigorously during wakefulness but stops in asleep. Inspiratory neuron is sporadically activated this does not happen in non rem sleep. The ventilatory response to hypercapnia is also suppressed in sleep. Increasing levels of co2 activate genioglossus muscle the least during rem sleep. Sleep affects mechanical reflex control of breathing most during wakefulness and. Airway narrowing in sleep, which leads to hypopneas and airway obstruction. Airway reflexes are reduced during sleep, leading to airways collapsing more easily. In sleep, takes less negative pressure to collapse airway because muscles are more relaxed and have less force to resist negative pressure. Smaller airways and reduced responsiveness to negative pressures predispose to obstructive sleep apnea. Increasing the release of gaba and glycine from inhibitory premotor neurons. Disfacilitation reducing release of neurotransmitters, eg. glutamate, seratonin, noradrenaline from excitatory premotor neurons.