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CSB351Y1 Lecture 8: Lecture 8

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redskunk879
15 Feb 2012
School
UTSG
Department
Cell and Systems Biology
Course
CSB351Y1
Professor
Mounir Abou Haidar

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Document Summary

How the viruses assemble themselves: this means that the protein recognized the nucleic acid to make up the virus particle. This is done in a testing tube (and this will hopefully teach us what is really happening inside the cell) History: frankel- conrat described the self-assembly of tmv in 1955. Rna and the protein makes a cloudy solution (the virus). Therefore, in right conditions a virus can self assemble (identical to the original virus). Therefore, protein + rna=> virus can assemble in to original form. Lauffer said that the process is entropy driven (it is endothermic). this means that you have to warm up the reaction ( if you put it on ice the reaction will not occur) . In the case of tmv the reaction has to occur in room temperature. This type of reaction has to absorb a little bit of heat from the environment in order to occur.

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Related Questions

What happens to the viral capsid when the virus enters a host cell? Host cell enzymes transcribe the viral genome into viral mRNA. What is the purpose of this mRNA?
At what stage will the viral proteins and the viral genome self assemble before or after the virus leaves he host cell ?
How are virus particles assembled? Where do they get proteins for the nucleocapsid and proteins embedded in the envelope?
Your body is capable of producing antibodies if you get infected with a virus. These antibodies typically bind to a surface protein on the virus particle. In most cases viruses have many copies of this surface protein on their surface, therefore it is possible that many antibodies can bind onto a single virus particle. In some cases hundreds of antibodies can coat an individual virus particle. Assume that the interaction between the virus and the antibody is NOT due to the hydrophobic effect.a. What do you think is the thermodynamic driving force for this assembly? Why?b. Imagine you would develop a strong fever during your infection, do you think that the affinity constant K for the binding reaction between antibody and virus would slightly increase or slightly decrease compared to the binding constant before you developed the fever? Explain.