CSB351Y1 Lecture 19: Lecture 19

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redskunk879

15 Feb 2012

School

UTSG

Department

Cell and Systems Biology

Course

CSB351Y1

Professor

Mounir Abou Haidar

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Document Summary

My transcription covers what was said in class. This is by no means a complete set of notes, and you will need his notes to supplement. Talking about video: kid with polio paralyzed the legs. Once taken it mutates to some variant form. The feces from this kid can be a source of virus because the vaccine is an attenuated vaccine. But it is the more effective form of the vaccine (compared to ipv inactivated polio vaccine). Hepatoviruses page 122: virus replicate in liver only. There is no indication that the virus replicate outside of the liver. It is resistant to some detergent inactivation like mild detergent, and heat up to 65 degrees. The virus can stand a certain degree of heat. This is how the virus can survive in environment. This is how they can be transmitted from person to person. eg loblaws where the person doesn"t even know that they have the virus.

Related Questions

Need help with both

1.) Explain the differences between killed/inactivated virus vaccines and live attenuated virus vaccines.

2.)List four vaccines that use killed/inactivated viruses and four vaccines that use live attenuated viruses.

Match the vaccine type with the appropriate description: attenuated whole-agent vaccine, conjugated vaccine, inactivated whole-agent vaccine, nucleic acid vaccine, subunit vaccine, and toxoid. Be sure to include the question text with your answers.

Composed of an inactivated toxin; tetanus vaccine is an example:
Highly effective, but carries more risk of back-mutation into a virulent form:
Uses microbes that have been killed by formalin or phenol:
Newest vaccines, using naked DNA:
Use only antigenic fragments of a microorganism:
Polysaccharides combined with proteins; Haemophilus influenzae type b is an example:

plumeagle724

From time to time, the CDC committee that makes recommendations about vaccines (ACIP) decides to âchange their mindsâ about the use of a particular vaccine, even though we might have been using it for a long time. Each time they do this, there is something about the âoldâ vaccine they didnât like, and something about the ânewâ vaccine that fixes the problem. For each of the following, explain (1) the difference between how the old and the new vaccines function, and (2) how the new vaccine avoids some problem with the old one. If the new vaccine introduces some problem of its own, describe that, too.

A. In 1983 a 23-valent pneumonia vaccine was developed using the polysaccharide capsules from 23 different Strep pneumoniae strains, and was used for elderly people. But in 2015 the ACIP recommended switching to a 13-valent polysaccharide-protein conjugate vaccine (Prevnar-13).

B. In 1997 the recommendation was made to switch from a whole-cell Pertussis vaccine, which had been in use since 1949, to an acellular subunit vaccine.

C. In 1961 we switched from an inactivated Polio vaccine (developed in 1955) to a live attenuated one. Then in 2000 we switched back to the inactivated one. Explain both ACIP decisions. D. In the near future, the decision may be made to switch from the current Flu vaccine (either the live attenuated or the inactivated one) to a DNA-based flu vaccine.

burgundyraccoon49

CSB351Y1 Lecture 19: Lecture 19

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