Lecture 8 - Drugs and the Brain

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6 Feb 2012
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Rewards increase acetylcholine in vta: rewards, brain stimulation increase ach increase dop. Block muscarinic block brain stimulation reward 100% less effect (important for longterm effect) Block nicotinic block 20% of effect. Brain-stimulation reward and food reward: blocked by muscarinic blockers (e. g. scopolamine) in. Slow muscarinic recs more critical for maintaining arousal in brain stimulation & food reward: weak effects of nicotinic blockers, mesopontine neurons activate dop release via fast nicotinic recs & slow muscarinic recs. Reward: animals will bar press to get stimulation (every second, very sensitive to how much stimulation received. If given cocaine or amphetamine, bar press less often (since drug level gets too high) a couple times a minute. Arousal of dop very important for rewarding effect of brain stimulation & food reward (not cocaine reward effects since downstream) So mediate only a small part of the arousal: cocaine & amphetamines stimulate dop release: Increase dop 5-10 times in nucleus accumbens.

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