HMB265H1 Lecture Notes - Lecture 10: Genotype Frequency, Allele Frequency, Genetic Drift

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9 Dec 2016
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HMB265H1 Full Course Notes
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Hardy-weinberg law: genetic drift, natural selection, mutation. Population genetics: study of genetics of a population and how alleles vary with time. Population: interbreeding group of same species within given geographical area. Gene pool: collection of all alleles in the members of the population. Gene flow: alleles can move between populations when individuals migrate and mate. Law clarifies the relation between genotype and allele frequency within generation and from one generation to the next. Five assumptions must be met for population to meet hardy-weinberg equilibrium. No genotype-dependent differences in ability to survive and reproduce. All natural populations violate one or more assumptions of hardy-weinberg law. Equations derived based on assumptions are very robust. Can be used as a null model as well. Let: p = allele frequency of first allele (ex. A) q = allele frequency of second allele (ex. -> all alelle frequencies equal 1, p and q are decimal percents. Equation itself is derived from squaring the binomial.

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