HMB265H1 Lecture Notes - Lecture 18: Ploidy, Monosomy, Gene Mapping
25 Nov 2017
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HMB265H1 Full Course Notes
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Hmb265: lecture 18 - changes in chromosome structure. Colchicine inhibits formation and keep 2 sets of chromosomes identical. Generate diploid plant that can propagate for ever and ever. Last week: changes in chromosome numbers (number of sets of number of individual chromosomes. No monosomy except from monosomy 21 (which die shortly after birth) Chromosome rearrangement is a major feature of evolution. Chromosomal rearrangement = major feature of evolution. Composed of different chunks of human chromosomes. Can reconstruct chromosome 1 of mouse if take fragments from humans and rearrange them back in a different order. Originally thought only changes in base pairs make difference, but actually rearrangements matter too. Consequence of misaligned chromosomes = aberrant recombination. Chromosome breakage and subsequent dna repair can result in all classes of chromosomal rearrangements. Can have all 4 different types of chromosomal rearrangements. Inversions (if break, and piece re-orients 180 degrees) B close to d instead of a.
