HMB300H1 Lecture Notes - Lecture 9: Entorhinal Cortex, Mifepristone, Endocytosis
Document Summary
Circuit: the ca3 has two roles, send axons to ca1 via sc, send axons out to communicate with other hippocampi via commissural fibers. Hippocampal models: tetanic (high frequency stimulation) is 100hz for a few seconds (100 action potentials a second, theta bursts patterns short bursts of 100 hz at millisecond intervals, mimics what happens when animal is trying to learn something. What accounts for ltp: nmda receptors have less mobility than ampa receptors, current model suggests that the increased amplitudes in ltp are due to increased numbers of. Ampar on post-synaptic membrane: gfp tagged glua1 (subunit of ampar) that were shown to move into synapses via a. Molecular mechanisms in ltd vs ltp: cellular and simplified culture models showed that there was movement of receptors. Major findings: during learning, he shoved electrodes into mice and noticed that synapses were getting stronger, sees ltp. Glua2 ampar: ampar-n-cadherin; a post-synaptic protein that stabilizes ampar at the synapse, ncam-180 doesn"t change.
