HMB321H1 Lecture Notes - Lecture 20: Heart Development, Congenital Heart Defect, Genetic Testing
8 Oct 2011
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We are born with only a set number of heart muscles, which, over time, will senesce and we eventually encounter issues (e. g. cvd) We need to understand how heart cells are in the embryo => can we learn something like this to add something endogenous into the heart to aid these issues. Adult heart muscle cells have different components than embryonic. Understanding gene programming can tell us how to turn off certain functions that are detrimental, though occur in adult heart cells. Once cells are speci ed, must organize into a tube. While the embryo is growing and pumping blood through, looping will occur (hence the fact that our blood pumps through left side rst) In some cases, incomplete septation occurs leaving an obvious hole in the septum. Unlike in wt heart, deoxygenated and oxygenated blood can be mixed. Can decrease survival due to reduction of oxygenated blood perfusing through body.
