Class Notes (836,580)
Canada (509,856)
HMB200H1 (140)
Lecture 8

Lecture 8 - Drugs and the Brain

3 Pages
112 Views
Unlock Document

Department
Human Biology
Course
HMB200H1
Professor
John Yeomans
Semester
Winter

Description
HMB200H1S L8 Feb1 2012Drugs and the BrainRewards Increase Acetylcholine in VTARewards brain stimulationincrease AChincrease dop If block cholinergic recsBlock muscarinicblock brain stimulation reward100 less effect important for Cocaineamphetamines stimulatereleasedoplongterm effect increase dop 510 times in nucleus accumbensBlock nicotinicblock 20 of effect if block this then stop effects locomotor arousal emotional confidencemotivational effects BrainStimulation Reward and Food Rewardspeed Blocked by muscarinic blockers eg scopolamine in Block reuptake of dop VTANicotinic also thru VTAsthere because theres Slow muscarinic recs more critical for maintaining 2 cholinergic signalsarousal in brain stimulationfood reward OtherStronger muscarinic effect thru M5 rec Weak effects of nicotinic blockersOpiate recs arent on neuronsindirect 23 gif Mesopontine neurons activate dop release via fast pathwaysnicotinic recsslow muscarinic recsGlutamatekey signal that changes in addiction learned rewardsCholinergic Blockers in VTA Inhibit BrainStimulation Paths from forebrain change glutamate neurons Rewardto abnormal addictive reward systemhow motivations are changed by drugs longterm changesMorphine or any opiate turns the GABA neurons offnormally inhibit dopamine neurons
More Less

Related notes for HMB200H1

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit