Lecture 15

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Department
Human Biology
Course
HMB321H1
Professor
Maria Papaconstantinou
Semester
Winter

Description
11 MAR 2011 HMB321 L15 Epigenetics in CancerMechanisms of epigeneticsModications are heritable eg Imprintingwithout change to the DNA just additive functal groupsCan include methylation histone deacetylation which interfere with transcriptionDNA methylationUsually occur at the CpG island site CphosphateGCpG islands are high concentrations of CpG sequences usually near gene promotersLots of methylation can be incurred to turn genes off effectivelyMethylation at CpGcytosine changes to 5methylcytosine which is not readableProcessTranscriptionally active chromatinunmethylated acetylated allows euchromatin transcrTranscriptionally competent chromatinstill transcribed because of acetylated despite methylation on geneHistone acetylationAddition of acetyl group causes difference in transcriptional abilityDeacetylation inactivates chromatin transcription even more so with methylationNo deacetylationmethylationstill some transcriptionHistone phosphorylationWays to modify histone via addition of phosphate group to serine moleculeCan reduce abili
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