IMM250H1 Lecture Notes - Lecture 4: Acute-Phase Protein, Interleukin 1 Beta, Interleukin 18
Document Summary
Cytokines cause vasodilation vasodilation makes capillaries more permeable so fluid, protein, and inflammatory cells enter tissue from the blood redness, heat, swelling, pain: inflammation. Chemokines attract more inflammatory cells amplifying the response. Bind to receptors on another cell biological effect (if the bind to the same cell=autocrine) Chemokines: attract other cells to where they"re produced (il-8) Pro-inflammatory cytokines: il-1b, il-6, il-18, tnf, mcp and il-8 (acts like a chemokine) Systemic cytokines induce acute phase response, il-6 is the. Inflammatory cytokines make blood vessels permeable blood vessel dilation redness and heat fluid leakage swelling (edema) Cytokines stimulate endothelial cells to express selectins (cams) Leukocytes roll along vein vessel until they reach a place where they can exit. Leukocyte integrin (cams) binds to selectin extravasation. Neutrophils, eosinophils, basophil, dendritic cells, macrophages, and mass cells are all derived from a common myeloid progenitor. 1)macrophages: kill pathogens, cytokine production, antigen presentation to t-cells, recognize damps (clean up crew)
