IMM250H1 Lecture : Notes taken during tutorial
Document Summary
this will decrease threshold of b cell activation. Less antigen is necessary to activate the b cell if the coreceptor is also transducing a signal. to modify pip2 into dag and ip3. dag will recruit another kinase, pkc two diff isomers, in b and t cells. whatever isomer of pkc have, lead to activation of nk kappa b induce expression of several genes. through ip3 release of small lipid molecule called ip3 that can diffuse through cytoplasm induce release of calcium from er. calcinurin binds to calcium change conformation, calcinurin is phosphatase activate nfat transcription factor that is normally in cytoplasm, in inactive form. plc gamma also activate gefs y activate g proteins ras and rac y activate mapk pathway y actiave of fos with jun. activated t cells will have all three transcription factors activated all cooporate to production of il2, essential proliferation factor for t cells.
