IMM250H1 Lecture : Lecture notes
Document Summary
C3b can be associate with c4b2a in this configuration, this is now comlex that has capaicity to activate compleement component five, or c5. When activated by alternative pathway, c3bbb form c3b2bb- also c5 convertase, One of the functions of complement is to facilitate the opsonization of pathogens by macrophages. Very constant theme throughout the complement pathway . C3a, c5a, c4a, - c5a is most effective interact with cells of endothelial and cause local inflammatory responses. Lysis of target pathogen lysis is complex series of events ivolving set of proteint hat result in lysis of targets. C5 is cleaved by c5 convertases by soluble product c5b functions to initate mebrane attack complex, mac, consequence of recruitment of series of proetins, c6, which binds to c5b, and this forms acceptor for c7. C7 is recruited amphilphilic coplex has both hydrophilic and hydrophobic portions and can peentrate into lipid bilayers . Wide variety of proteins that can regulate complement pathway c1 inhibitor c1.