IMM250H1 Lecture Notes - Lecture 8: Disseminated Intravascular Coagulation, Avian Influenza, Innate Immune System
Document Summary
Part 1: when the innate immune system overreacts. Sepsis, severe form of systemic in ammation against a microbe. May lead to septic shock decreased tissue perfusion and oxygen delivery, multiple organ dysfunction and death. Incidence, higher than cancer, higher mortality rates too. Symptoms include typical u-like, but later shortness of breath, pneumonia-like symptoms death due to lung failure. The new spanish u? spanish ue killed 50-100 million people in 1918, the worry with the avian. U is that it could be more virulent. Moratorium banning research on h5n1 ended 2 years ago, controversial decision. Adequate = controlled infection, clearance inadequate = ongoing release of microbial toxins. These disease lead to an innate immune-mediated cytokine storm . Induces a positive feedback loop, ampli es cytokine production moves from local to systemic response involves multiple organs tnfa, il-1b, il6, il8 are key mediators. High levels of cytokines in the blood disseminated intravascular coagulation (leads to coagulopathy, vascular instability)
