IMM250H1 Lecture Notes - Lecture 5: Nalp3, Phagosome, Inflammatory Bowel Disease
10 May 2016
School
Department
Course
Professor
Document Summary
C1 inhibitor works on classical pathway of complement activation. Factor h protein in bloodstream binds to c3b and targets factor i to cleave it (degradation), shutting off complement system. Protectin or cd59 interferes with mac on our own cells, so no pores can form. C1-inhibitor deficiency means cannot turn off classical pathway of activation, so if getting some bacterial infection, crazy reaction and no inhibition. Leads to overswelling, leakage, blockage of airways, etc. Type i interferons (interferon a and interferon b: produced mainly by cells with intracellular infection (usually viral, works in innate fashion to enhance resistance to viral infections by: Inducing resistance to viral replication in all cells (switching off protein synthesis, virus can no longer hijack protein synthesis machinery to replicate itself) Increases mhc class i expression and antigen presentation in all cells (activates adaptive immune system) Activates nk cells to kill virus-infected cells (they can recognize virally infected cells better, and increased ability to kill them)
