IMM350H1 Lecture Notes - Lecture 7: B-Cell Receptor, Cd19, Syk
Document Summary
1 leukocyte receptor complex: ilt: ig-like transcripts, lair: leukocyte-associated ig- like receptors. Ncr natural cytotoxicity receptors: members in the two families, recognize infection & tumour cells, ligands poorly defined. Mic-a, mic-b, raet1 family members: siglec: sialic acid-binding ig- like lectins. 2 natural killer receptor complex: encodes killer lectin-like receptors (mice have ly49 instead of kir) Nk cells are innate (but cytotoxic) lymphoid cells (ilcs) T-dependent antigen (td) can only activate b cells with help from t cells -> usually activates follicular. T-independent antigen (ti) can activate without help -> usually. B cell activation facilitated by bcr co-receptor cr2/cd19/cd81. B cell receptor + co-receptor stimulation induces phosphorylation of ig /ig and cytoplasmic tail of. This phosphorylates slp-65 activates b1 and marginal zone cells (mucosal tissues), can recognize multivalent antigens like blood-borne polysaccharides. Spleen has dependent & independent (follicular & marginal zones)
