MGY299Y1 Lecture Notes - Hbb, Pseudogene, Pax Genes
3 Jun 2013
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Give ultra exquisite control over gene expression at price of complex structure. Gene density gene desert no protein coding genes there. Gene like dystrophin this large takes 24 hours to transcribe at full rate so long to make this gene seems like a burden, - seems to not need this gene very much, true. Relate to how they might behave, how present in genome. Lots of time generate non-functional gene copies pseudogenes specific function may be assigned to them for regulation but rare. Beta globulin gene cluster proximity to each other relates to how regulated through development. Coding genes in blue pseudogenes in white has lost features to be expressed. Also see fragments of genes fragment order still maintained . Tandem in contrast to them, widely dispersed among different chromosomes. Not sure selection npressure to maintain reading frames if gene is absolutely essential but probably true lots of dispersed gene family members will be across multiple species ___________________
