MGY377H1 Lecture Notes - Lecture 28: Type Three Secretion System, Cytochrome C Oxidase, Endoplasmic Reticulum
1 Feb 2018
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The bacteria geta engulfed and gets put into a phagosome. Endosomes which are small memberane bubbles that have different functions and have different proteins will fuse at different times to form a (cid:373)aturi(cid:374)g e(cid:374)doso(cid:373)e. this is(cid:374)"t a(cid:374) a(cid:272)(cid:272)ide(cid:374)tal pro(cid:272)ess, its tightly regulated. The endosomes fuse and they dump their contents into the phagosome. They cary lots of bacteriocidal, fungalcidal and acids and proteases, ros, and nitric oxide species. All of these will neutralize the invade and kill it 99. 99% of the time. Theres the cytochrome oxidase that produces hydroxyl radicals and oh, theres rinos that produces nitric oxide, and they starve the bacteria of metal, proteases are produced and the ph within the phagosome drops significantly. A well adapted pathogen cant just resist one of these, it has o resist all of these. They either eliminate the threat, repair the threat, or become resistant t the threat.
