MGY378H1 Lecture Notes - Golgi Apparatus, Cell Membrane, Endosome
3 Jun 2013
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Document Summary
Nef alone can recapitulate all of hiv pathogenesis seen in recombinant mice. Sidney cohort slow progression of disease . Removal of cd4/mhc1/mhc2 facilitates release of virus. Reduction of mhc class 1 and 2 no longer presents viral antigen to surrounding immune cells. Arrest of apoptosis in infected cells keeping cell alive long enough to produce maximum number of immune particles. Modulation of t cells ignalling thru host kinases. Ap2 bridges cd4 interaction into calthrin coated pits. Draws cd4 into endosome, into lysome for degradation. In context of mhc, traffick of mhc of trans golgi network into surface from surface into lysossomes where degraded. Major impact in redirecting trafficking of lysosme. Also upregulating tetherin interacting with aip required for viral assembly and promoting virus release into environment. Signalling events role in terms of recruiting cells into env. Pili virus serves on contact cell on space upregulation of dc sign: to enhance presentation of new cells in environment.
